Project C5: Characterization of action control networks in genetically determined parkinsonism
Prof. Dr. Alexander Münchau
Dept. of Neurology, University of Lübeck
Prof. Dr. Christine Klein
Dept. of Neurology, University of Lübeck
In the first two funding periods, we found evidence for increased activity of action selection networks in patients with genetically undefined parkinsonism, Parkin- and PINK1-associated parkinsonism, L-dopa-responsive dystonia, and X-linked dystonia parkinsonism. We now focus on network-related processes leading to disease manifestation by comparing asymptomatic mutation carriers with symptomatic patients with Parkin- and PINK1-associated parkinsonism, X-linked dystonia parkinsonism, and GBA-associated parkinsonism. To this end, we will use behavioral tasks, EEG, TMS, pupillometry, and neuromelanin-sensitive high-resolution MRI.